Scientific Activities

Ana Mišir Krpan, Anja Tea Golubić, Maja Baučić, Jakob Nemir, Goran Mrak, Marijan Žuvić, Dražen Huić from University Hospital Center in Zagreb, Croatia together with Marina published their work

18F-FET and 18F-choline PET/CT in patients with MRI-presumed low-grade gliomas: a pilot study

in Croatian Medical Journal.

 

Thank you University Hospital Center Zagreb, Croatia for this long lasting friendship!

 

Iason would like to announce that great scientific team from Kepler University Hospital, Linz, Austria

Ognian Kalev, Berndt Tomancok, Michael Sonnberger, Markus Hutterer, Daniela Ehrlich, Robert Pichler

together with our Marina Hodolic published a new article

“Giant silent corticotrope pituitary adenoma in a patient with complicated clinical course” in journal Endokrynologia Polska.

 

Congratulations!

 

 

 

IASON is very proud to announce that the first in human use of our new radiopharmaceutical 68Ga-NT-20.3 has been performed!

 

Prof. Dr. Marina Hodolic presents the results in her article

 

“Safety and tolerability of 68Ga-NT-20.3, a radiopharmaceutical for targeting neurotensin receptors, in patients with pancreatic ductal adenocarcinoma: the first in human use”

 

The article was written together with our great collaborators from the Department of Nuclear Medicine, Nanjing First Hospital, Nanjing, China and was published in the famous European Journal of Nuclear Medicine.

 

​Article Marina Hodolic

The IASON Scientific team wishes you a Merry Christmas and a Happy New Year 2020!

((c) drawings by Lucia and Lenka)

 

Our scientific collaborators from Policlinico San Matteo, Pavia, Italy together with Marina realized and presented in the manuscript work

 

“Effects of photons’ irradiation on 18F-FET and 18F-DOPA uptake by T98G glioblastoma cells”  Article published

 

Bravi:

PASI Francesca, PERSICO Marco Giovanni, MARENCO Manuela, VIGORITO Martina, FACOETTI Angelica, HODOLIC Marina, NANO Rosanna, CAVENAGHI Giorgio, LODOLA Lorenzo, APRILE Carlo!!!

 

Our innovative scientific work was presented at the European Congress of Nuclear Medicine 2020, delivered as oral presentations:

 

VASINA, J., HODOLIC, M, JANCALEK, R., MACKERLE, Z., HENDRYCH, M., et al. 18F-FET of 18F-FLT PET/CT in diagnosis of low-grade gliomas? A pilot study.

 

BOSSERT, I., HODOLIC, M, CHYTIRIS, S, D’AMBROSIO, D., MARCHETTO, A., et al. Optimization of 18F-Fluorocholine PET/CT protocol in parathyroid imaging.

 

HODOLIC, M, GOLUBIC, A. T., MISIR KRPAN, A., ZUVIZ, M, BAUCIC BOZIC, M, MRAK, G, NEMIR, J, HUIC, D. Primary diagnosis of low-grade glioma: 18F-FET or 18F-FCH PET?

 

WANG, F, WU, W, VIRGOLINI, I, HODOLIC, M. The first in human use of ⁶⁸Ga-NT-20.3: radiopharmaceutical for imaging of neurotensin receptors. Safety data.

 

 

We would also like to express our sincere gratitude to

University Hospital Brno, Czech Republic

Scientific Institute Maugeri, Pavia, Italy

University Hospital Centre, Zagreb, Croatia

Nanjing first Hospital, Nanjing, China

 

 

The EANM 2020 was a success for all of us!

Journal final EMJ-Radiology-article-Marina Hodolic

“18F-FET or 18F-FCH PET/CT in the primary diagnosis of low-grade glioma: a pilot study”

 

HODOLIC Marina, MISIR KRPAN Ana, GOLUBIC Anja, BAUCIC BOZIC Maja, NEMIR Jakob, MRAK Goran, ZUVIC Marijan and HUIC Drazen, continue the scientific collaboration between IASON and its valuable customers!

IASON will be present at the EANM (European Association of Nuclear Medicine) Congress in Vienna, which will take place from October 17^th to 21^st 2020.

We are extremely proud to announce our scientific work there, made in collaboration with the Nanjing First Hospital, Nanjing, China, the University Hospital Centre Zagreb, Croatia, the University Hospital of Brno, Czech Republic, and the Istituti Clinici Scientifici Maugeri in Pavia, Italy.

We are happy to tell you that IASON’s Marina Hodolic will present our work on PET diagnostics of low grade gliomas, made in collaboration with the University Hospital Center of Zagreb, Croatia, at this year’s European Congress of Radiology in Vienna.

 You can watch Marina’s online presentation from July 15^th following this link: https://connect.myesr.org/ecr-2020/

We are very happy to announce the publication of a new manuscript, written by Marina Hodolic, Valentina Ambrosini and Stefano Fanti, on the ‘Potential use of radiolabelled neurotensin in PET imaging and therapy of patients with pancreatic cancer’ (see excerpt here). IASON is pleased that this article was announced as ‘Highlight article of the current issue’ of Nuclear Medicine Communication Journal (see here).

 

 

Dear friends,

We are happy to announce that IASON will be present at the

35th international Austrian Winter Symposium of Nuclear Medicine and Molecular Imaging in Zell am See, from January 22th-25th 2020.

We are honored to present our work on ¹⁸F-FET and ¹⁸ F-FCH in patients with low grade gliomas, made in collaboration with the University Hospital Center of Zagreb, Croatia.

See you in Zell am See! 🙂

Update 28.01.2020: Please see some pictures from the congress here: pic1 pic2

 

 

One more year is behind us and Christmas is just around the corner…

I would like to thank all of IASON’s scientific collaborators for the great work we did together!

I am looking forward to again making this world a better place for the patients, with the help of all of you, in the year 2019!

Marina

EBA 2019_Certificate National Winner for Austria

 

IASON’s Assoc.-Prof. Marina Hodolic will give a talk on the topic of

“The role of PET/CT in diagnosis and treatment of brain tumours” 

The scientific meeting organized by the Macedonian Association of Nuclear Medicine will take place at the University Institute of Positron Emission Tomography of Skopje, Macedonia, on December 12^th, 2019.

Update 19.12.2019: Marina’s talk was a big success! Please see some pictures here: pic1 pic2 pic3

Marina also presented IASON’s work on ¹⁸F-FET – made in collaboration with the University Hospital Centre Zagreb, Croatia and the Masaryk University Brno, Czech Republic – at the

Nuclear medicine days in Nitra, Slovakia

which took place from November 27th to 29th, 2019.

IASON´s great collaboration with a group of scientists from Pavia, Italy, resulted in the manuscript

“Evidence of 68Ga-DOTA-NT-20.3 uptake in pancreatic adenocarcinoma AsPC-1 cell line – in vitro study”

published in the journal “Current Pharmaceutical Biotechnology”.

Please see the abstract here

As a result of a successful collaboration between IASON and great group of scientists from Italy, an article has been published in the Journal of Endocrinological Investigation:

PET/CT with 18F-Choline localizes hyperfunctioning parathyroid adenomas equally well in normocalcemic hyperparathyroidism as in overt hyperparathyroidism

Please read the article here.

The authors:

· Luca Chiovato, Unit of Internal Medicine and Endocrinology, ICS Maugeri and of University of Pavia, Italy

· Laura Croce, Unit of Internal Medicine and Endocrinology, ICS Maugeri and of University of Pavia, Italy

· Spyridon Chytiris, Unit of Internal Medicine and Endocrinology, ICS Maugeri, Pavia, Italy

· Luigi Mansi, Inter-Universitary Research Center for Sustainable Development (CIRPS), Napoli-Roma, Italy

· Giuliano Mariani, Regional Center of Nuclear Medicine, University of Pisa, Pisa, Italy

· Marina Hodolic. Nuclear Medicine Research Department, Iason, Graz, Austria and Nuclear Medicine Department, Faculty of Medicine and Dentistry, Palacký University Olomouc, Czech Republic and Nuclear Medicine Department, Policlinico S. Orsola Malpighi, University of Bologna, Bologna, Italy

· Irene Bossert, Unit of Nuclear Medicine, ICS Maugeri, Pavia, Italy

· Giuseppe Trifirò, Unit of Nuclear Medicine, ICS Maugeri, Pavia, Italy

We are happy to announce that our work “¹⁸F-FET and ¹⁸F-choline PET/CT in patients with newly diagnosed low-grade gliomas: a pilot study”, which was written in collaboration with a group from the University Hospital in Zagreb, Croatia, is going to be presented at the European congress of neurosurgery in Dublin in September 2019.

 

 

We are proud to announce that our work “New radiopharmacs in low grade gliomas” made in collaboration with University Hospital Centre Zagreb, Croatia, will be presented on the 1st Neurooncology International Course in Dubrovnik.

Please see the program here:Program 1st Neurooncology International Course.

 

Assoc. Prof. Marina Hodolič will give a talk “¹⁸F-FET or ¹⁸F-FCH PET in the diagnosis of low-grade gliomas?” at Czech congress of oncology which will take a place in Brno from April 10-12, 2019.

Please see the program here: https://www.onkologickedny.cz/program

 

Assoc. Prof. Marina Hodolič will give a talk “18F-FET and 18F-choline PET/CT in patients with newly diagnosed low-grade gliomas: a pilot study“ at Balkan congress of nuclear medicine which will take a place in Turkey, Bodrum from April 10-14, 2019.

 

We are happy to let you know that Iason GmbH presented the results of the cooperation with University Hospital Center Zagreb at the 19th Croatian Congress of Oncology, which took place in Poreč, April 5-7, 2019. e-poster

 

We are proud to announce that the following of our scientific works will be presented at the Italian Congress of Nuclear Medicine, which is taking place in Rimini (IT) from April 11th to14th 2019:  

“The comparison of ¹⁸F-FET and ¹⁸F-choline in patients with newly diagnosed low-grade gliomas: a pilot study” Poster LGG Rimini 2019

“Targeting neurotensin receptor positive tumours: in vitro binding of pancreatic ductal adenocarcinoma with ⁶⁸Ga-DOTA-neurotensin engineered fragment” Poster_PDAC_AIMN_2019

“Targeting neurotensin receptor positive tumours: in vitro binding of malignant pleural mesothelioma with ⁶⁸Ga-DOTA-neurotensin engineered fragment” Poster-mesothelioma-AIMN_2019

“Effects of irradiation with photons and carbon ions on ¹⁸F-DOPA uptake by T98G glioblastoma cell line. Comparison with ¹⁸F-FET in vitro study” Poster AIMN 2019

“Prognostic value of [18F]fluorocholine PET parameters in metastatic castrate–resistant prostate cancer treated with docetaxel”

 

We are pleased to announce the publication of a great book entitled ‘Gliomy’ (see picture here), for which our Marina Hodolič wrote a chapter about 18F-FET in gliomas…do not miss it!

We are pleased to let you know that our article “Prognostic Value of 18F-Fluorocholine PET Parameters in Metastatic Castrate-Resistant Prostate Cancer Patients Treated with Docetaxel” has been published in “Contrast Media & Molecular Imaging”.

Please access our article at the following location:

https://www.hindawi.com/journals/cmmi/2019/4325946/

 

We are happy to inform you that our work, as a result of a fruitful collaboration with a scientific group from IRCCS ICS Maugeri, Pavia, Italy, the following work has been accepted for the European Congress of Radiology, which will take place in Vienna from February 27th to March 3rd 2019.

Prognostic value of [18F]Fluorocholine PET parameters in metastatic castrate–resistant prostate cancer treated with docetaxel

E. Quaquarini, D. D’ambrosio, F. Sottotetti, F. Gallivanone, M. Hodolic, C. Porta, R. Palumbo, A. Bernardo, G.Trifirò

 

 

We would like to thank the Izotopcentrum from Nitra for their kind invitation to this great event.

Our Assoc. Prof. Marina Hodolic gave a talk on IASON’s tracer 68Ga-DOTA-NT 20.30.

 

 

Scientific work with our customers:

“Can we image Malignant Pleural Mesothelioma with 68Ga-DOTA-Neurotensine analogue? In vitro study”

M. Marenco; M. G. Persico; G. Cavenaghi; V. Frangipane; F. Meloni; L. Lodola; M. Hodolič.

“PET/CT With 18F-fluorocholine May Detect Parathyroid Adenomas Also In Preclinical Or Subclinical Stage”

Bossert I; Mansi L; Hodolič M; Chytiris S; Croce L; Chiovato L; Mariani G; Trifirò G.

Assoc. Prof. Marina Hodolič gave a talk on “18F-FET and 18F-FCH uptake on glioblastoma multiforme T98G cell line: in vitro study” at the Czech congress of nuclear medicine in Mikulov, which took place from September 19th to 21st.

Please see the program here: http://dnynm.cz/odborny-program-hlavni-kongresovy-sal

Please see a picture from the Congress here.

IASON would especially like to thank their business partner Lacomed spol s.r.o. for their support in this congress.

 

We are pleased to inform you that our work “68Ga-DOTA-NT-20.3. An innovative probe for neurotensin receptor-positive tumor imaging in the diagnosis of malignant pleural mesothelioma” has been selected for oral presentation at the European Respiratory Society International Congress in Paris 2018, September 15th-19th 2018.

Authors: M. Marenco; V. Frangipane; M. Hodolic; S. Inghilleri; G.Stella; F. Meloni; L. Lodola

We are thankful to the Nuclear Medicine Department of the IRCCS Policlinico San Matteo Foundation and the Unit of Respiratory Diseases of the IRCCS Policlinico San Matteo Foundation in Pavia, Italy, for the fruitful collaboration!

Please see a picture of the presentation here.

 

IASON was present ​at the 50th anniversary of the Nuclear Medicine department in Osijek, Croatia.

Assoc. Professor of Medicine, Marina Hodolič, M.D., Ph.D., IASON’s Clinical Research Supervisor, was invited to give a talk on the occasion of this big anniversary.

Please see the program here.

IASON’s Marina Hodolič is going to speak the 14th Panhellenic Congress of Nuclear Medicine, which is taking place from 14th to 17th June 2018 in Heraklion, Crete, Greece. Please see the program here.

Please see a picture from the congress here, showing Sofia Koukouraki and Marina Hodolic.

We are proud to announce that IASON’s Marina Hodolic gave a presentation as an invited speaker on 16th May 2018 at the oncological days in Brno, Czech Republic!

Please see the congress program here.

IASON will be present at the VII Congresso Nazionale GICR in Ferrara (IT) on May 11-12th with presentations of the following scientific work:

“Uptake di [18F]-FCH, [18F]-FET e [18F]F-DOPA in cellule di glioblastoma multiforme umano in condizioni basali e dopo irraggiamento con fotoni e ioni carbonio” from the authors Vigorito M.1, Pasi F.1,2*, Persico M.G.3,4, Marenco M.3, Facoetti A.5, Hodolic M.6, Nano R.1, Lodola L.3

see poster here

and

“Neurotensin receptor imaging: 68Ga-DOTA-NT-20.3 uptake on pancreatic ductal adenocarcinoma cell line”, written by Marenco M.1*, Persico M.G.1,2, Hodolič M.3,4, Frangipane V.1, Cavenaghi G.1, Facoetti A.5, Aprile C.5, Lodola L.1

see poster here

 

IASON is pleased to announce that a great scientific collaboration with our customers resulted in several scientific activities at the EANM – Annual Congress of the European Association of Nuclear Medicine (October 21st to 25th 2017 in Vienna, Austria):

IASON is pleased to announce that a great scientific collaboration with our customers resulted in several scientific activites at the EANM – Annual Congress of the European Association of Nuclear Medicine, which took place from October 21st to 25th 2017 in Vienna, Austria:

18F-FET, 18F-FCH and 18F-DOPA uptake on human glioblastoma T98G cells: in vitro study

Oligometastatic disease (OMD) in prostate cancer (PCa) detects by 18F-Choline (FCH PET/CT in patients with PSA levels < 5ng/mL

Value of 18F-fluorochonline PET/CT for Targeted Prostate Rebiopsies in patients with rising PSA levels

Comparison between 18F-Choline (FCH) PET/CT and conventional imaging (CI) in intermediate-high risk prostate cancer (PCa) patients: design and preliminary data of a phase III Italian Multicenter Randomized Trial

Comparison of 99mTc-sestaMIBI and 18F-Fluorocholine PET/CT in localization of hyper-functioning parathyroid glands

 

 

IASON is present at the XXXV National Conference of Cytometry in Paestrum, Italy, from October 3rd to 6th 2017, with the following scientific work:
18F-FET,18F-FCH AND 18F-DOPA UPTAKE IN HUMAN GLIOBLASTOMA T98G CELLS

This is a result of a collaboration with:

– S.C. Medicina Nucleare, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

– Scuola Universitaria Superiore IUSS, Pavia, Italy

– S.C. Radioterapia Oncologica, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

– Lab. Neuro-Radio Biologia Sperimentale, Dipartimento di Biologia e Biotecnologie “L.Spallanzani”, Università degli Studi di Pavia, Italy

– CNAO, Centro Nazionale di Adroterapia Oncologica, Pavia, Italy

Authors:

Persico M.G., Pasi F., Lodola L., Hodolič M., Facoetti A., Baio A., Aprile C., Nano R.

IASON Scientific Advisor Assoc.-Prof- Dr. Marina HODOLIC is going to give a talk about 18F-FET in patients with gliomas.

After the great interest in her talk at the CNAO in Pavia, she has been invited to give a talk at the Fondazione Salvatore Maugeri in Pavia, Italy.

When: October 12th 2017, at 11 am

Where: Fondazione Salvatore Maugeri Pavia, aula Capodaglio

 

 

On September 18th 2017 at CNAO Pavia, IASON Scientific Advisor Assoc.-Prof- Dr. Marina HODOLIC presented “IASOglio in patients with gliomas”: the audience showed a great interest in this topic!

The National Centre of Oncological Hadrontherapy (CNAO) located in Pavia is the first Centre of Hadrontherapy in Italy which has been provided with a beam that is able to irradiate tumours with protons or carbon ions.

Hadrontherapy uses protons and atomic nuclei (ions) called hadrons (from the Greek hadrós, strong), which are subjected to a strong nuclear force, for treating radio-resistant or inoperable tumours. Nowadays the interest in hadrontherapy is growing rapidly. By 2020 it is expected that there will be almost 100 centres around the world, with over 30 of these being located in Europe.

On Saturday May 6th (6 p.m.) IASON’s Scientific Advisor Assoc.-Prof. Dr. Marina HODOLIC is going to give an oral presentation on 18F-FET AND 18F-FCH UPTAKE ON HUMAN GLIOBLASTOMA T98G CELLS: IN VITRO STUDY at the 9th International Congress of the Croatian Society of Nuclear Medicine (May 4th to 7th in Rovinj, Croatia), which is the result of a collaboration with the policlinico San Matteo (Pavia, Italy).

IASON is also present at the 6th Balkan Congress of Nuclear Medicine in Sofia, Bulgaria, from April 20-23th, where Dr. Hodolic is going to talk about ’18F-FET in gliomas’. Time/date: April 20th at 5.45 p.m.

Please see the invitation here

 

 

Rimini congress poster Pavia

Rimini congress poster Padova

 

IASON is proud to announce that Assoc-Prof. Dr. Marina Hodolic has contributed to the book Nuclear Medicine in Prostate Cancer. An excerpt of the chapter can be read here

 

Uptake of 18F-FET and 18F-FCH in Human Glioblastoma T98G Cell Line after Irradiation with Photons or Carbon Ions:

https://www.hindawi.com/journals/cmmi/2017/6491674/

Merry Christmas 🙂

Marina with Students

Vellani, Cecilia; Hodolic, Marina; Chytiris, Spyridon; Trifirò, Giuseppe; Rubello, Domenico; Colletti, Patrick M

Early and Delayed 18F-FCH PET/CT Imaging in Parathyroid Adenomas.

 

 

Marina clearly had a fun day teaching a PET/CT lesson for a group of international students at the Palacky University in Olomouc, CZ 🙂

Pic

In 2016, IASON Scientific Advisor Assoc.-Prof- Dr. Marina HODOLIC held lectures on 18F-PET/CT in patients with glioblastoma at the following venues:

– Banja Luka (BIH), 2nd February (hospital meeting)

– Zagreb (HR), 5th April (hospital meeting)

– Lecce (IT), 7th – 9th April, 25th Corso di aggiornamento nazionale AIMN in medicina nucleare (invited lecture)

– Pisa (IT), 31st May (hospital meeting)

– Modena (IT), July 13th (hospital meeting)

– Ospedale San Donatto, Arezzo, October 4^th (hospital meeting)

– Instituto Neurologico Carlo Besta, Milano, November 17^th (hospital meeting)

 

IASON will be present at a medical meeting in Trento, Italy, on November 18th. Please see the program here:

Meeting program (excerpt)

Please see the official invitation here:

Invitation to Lecture

As every year, IASON participated in the annual congress of the European Association of Nuclear Medicine (EANM), which took place from October 15th to 18th in Barcelona.

The congress was a great success and also featured scientific contributions from IASON (see links below).

EP 004_Evangelista_Hodolic

EP 247_Evangelista_Hodolic

IASON Scientific Advisor Assoc.-Prof- Dr. Marina HODOLIC is the co-author of an abstract which has been accepted at the CHEST 2016 Annual Meeting in Los Angeles!

The title of the abstract: Sarcoidosis – Follow up with 18F-FDG PET/CT after different therapy   

The authors: Marjeta Terčelj¹, Nadja Koren Pucelj¹, Maša Bizjak¹, Kaja Šifer¹, Marina Hodolič², Barbara Salobir¹

 ¹Klinični oddelek za pljučne bolezni in alergijo, Univerzitetni klinični center Ljubljana, Zaloška cesta 7, Medicinska fakulteta, Ljubljana, Slovenija

²Nuclear medicine research department Iason, Graz, Austria, Medical Faculty Olomouc, Czech Republic

See the official invitation to lecture here

IASON Scientific Advisor Assoc.-Prof- Dr. Marina HODOLIC is the (co-)author of a new scientific article: 18F-fluorodeoxyglucose and 18F-flumazenil positron emission tomography in patients with refractory epilepsy

Link to article

 

IASON Scientific Advisor Assoc.-Prof- Dr. Marina HODOLIC is the (co-)author of a new scientific article in December 2015: 18F-FDG PET/CT in the Initial Assessment and for Follow-up in Patients With Tuberculosis.

Link to abstract

 

New article co-written by IASON Scientific Advisor Assoc.-Prof- Dr. Marina HODOLIC: 18F-FET and 18F-FCH uptake in human gliobastoma T98G cell lines

Link to article

IASON’s Scientific Advisor Assoc.-Prof- Dr. Marina HODOLIC is co-author of the following scientific article (published in ‘Abdominal Imaging’; Springer Verlag 2015):

Read PDF

IASON’s Scientific Advisor Assoc.-Prof- Dr. Marina HODOLIC published an article on Hypoxia PET Tracers in EBRT Dose Planning in Head and Neck Cancer (published in March 2015).

IASON’s Scientific Advisor Assoc.-Prof- Dr. Marina HODOLIC represented IASON at the EANM (European Association of Nuclear Medicine) conference in Hamburg, held in October 2015.

 

 

IASON Scientific Advisor Assoc.-Prof- Dr. Marina HODOLIC is co-author of the following scientific article (published in the Journal of Nuclear Medicine, on December 31st 2014):

Link to article

Read the following chapter on “Prostate Cancer”, co-authored by IASON’s Scientific Advisors Assoc.-Prof- Dr. Marina HODOLIC, published in ‘Nuclear Oncology’ (Wolters/Kluwer Health, 2015)

Read PDF

 

The following article on “Malignant disease as an incidental finding at 18F-FDG-PET/CT scanning in patients with granulomatous lung disease” is co-authored by IASON’s Scientific Advisors Assoc.-Prof- Dr. Marina HODOLIC  and was published on February 2nd 2015:

Read PDF